Best Odds for Detroit Lions vs Buffalo Bills
Compare moneyline, spread, and total prices for Detroit Lions vs Buffalo Bills before kickoff. 21+. Bet responsibly.
Kickoff: 2026-09-18T00:15:00.000Z
Last updated: 2026-09-10T01:50:56Z
Moneyline comparison
- away: best +164 from fanduel; second best +145 from espnbet; worst +135 from gtbets
- home: best -160 from gtbets; second best -162 from draftkings; worst -196 from fanduel
Spread comparison
- away: best +3.5 at -110 from fanduel; second best +3.5 at -115 from espnbet; worst +3 at -110 from betus
- home: best -3 at -105 from lowvig; second best -3 at -109 from williamhill_us; worst -3.5 at -110 from fanduel
Total comparison
- over: best +51.5 at -107 from lowvig; second best +51.5 at -109 from gtbets; worst +52.5 at -116 from rebet
- under: best +52.5 at -110 from fanduel; second best +52.5 at -112 from betrivers; worst +51.5 at -110 from betus
Moneyline payout comparison
$100 total return at the best away moneyline: $264.00.
Frequently asked questions
What are the best odds for this matchup?
The best odds are the strongest distinct quotes currently shown for Detroit Lions vs Buffalo Bills.
Why do sportsbook prices differ?
Sportsbooks set lines independently and update at different times.
How often are these odds updated?
This page shows the latest timestamp returned by the current odds feed.
How does Odds Concierge calculate the best line?
Valid quotes are compared by line and price, and exact ties are collapsed into one distinct tier.
Is Odds Concierge a sportsbook or betting advisor?
No. Odds Concierge is an education-first odds comparison tool.